Infectious mononucleosis

Infectious mononucleosis is a viral disease most often caused by the Epstein — Barr virus, and less commonly by cytomegalovirus. It is transmitted through saliva during close contact, and manifests as prolonged weakness, a high temperature, a sore throat and enlargement of the lymph nodes, liver and spleen. The diagnosis is confirmed by a doctor based on blood tests, so with such symptoms an examination by a physician or paediatrician is needed.

Which doctorInfectious disease specialist, also — paediatrician
UrgencyRoutine appointment
Reviewed byMedical editorial team
Updated

For typical symptoms, book a routine appointment with an infectious disease specialist or a paediatrician. You should seek help urgently if there is severe abdominal pain, difficulty breathing, marked pallor, or a rash appearing while taking antibiotics.

Main

  • Epstein — Barr virus is transmitted through saliva, affecting the mucous membrane of the mouth and pharynx, then the lymphoid tissue.
  • Children, adolescents and young adults are affected more often; in young children the illness often runs an abortive course, like a common cold.
  • Fever, sore throat, enlarged lymph nodes, weakness persist longer than with a common cold.
  • The diagnosis is confirmed by examination, a complete blood count with atypical cells and serological tests.
  • An infectious disease specialist manages the patient, in children — a paediatrician; severe abdominal pain or difficulty breathing requires urgent care.

What is infectious mononucleosis

Infectious mononucleosis is a viral illness in which weakness, fever and enlarged lymph nodes persist for a long time. Below we explain what lies behind this condition, where it comes from and who is affected more often.

What happens in the body

The Epstein — Barr virus enters the body through saliva and settles on the cells of the mucous membrane of the mouth and pharynx. There it multiplies and then penetrates the lymphoid tissue, which is abundant in the pharynx and tonsils. Because of this, the throat becomes red and sore, and the tonsils look swollen and covered with a coating. At the same time, the virus reaches the lymph nodes, and they become noticeably enlarged, especially in the neck. The immune system responds to the invasion, and this struggle stretches over weeks, causing weakness and a high temperature. The liver and spleen may also be involved in the process, so they sometimes become enlarged and cause heaviness in the side. Understanding this mechanism helps one to take the prolonged course more calmly: the body needs time to cope with the virus.

What causes it to develop

  • Epstein — Barr virus: it is this that triggers the illness, entering the body and affecting the cells of the mucous membrane and lymphoid tissue.
  • Contact with the saliva of an infected person: the virus is shed in saliva, so infection is possible through kissing and close contact.
  • Sharing personal hygiene items or dishes: a shared cup, spoon or towel becomes a route of transmission if they are used by a carrier of the virus.
  • Close household contact in a family or group: in a flat, a hall of residence or a nursery, the virus passes from person to person more easily.
  • Shared toys among children: little ones put them in their mouths and share them with each other, which speeds up the spread of the virus in the group.
  • Low contagiousness of the virus: it is not transmitted as easily as a cold, so outbreaks occur more often with prolonged close contact.

Who encounters it more often

Infectious mononucleosis is detected more often in children, adolescents and young adults, but a person of any age can fall ill. In small children the illness often passes in a mild form, and sometimes it is mistaken for an ordinary cold. In adolescence and in young people it more often produces a pronounced picture with fever, sore throat and enlarged nodes. Its spread is influenced by close groups: a nursery, school, hall of residence or barracks increase the chance of transmission of the virus. Crowding and shared household items also play a role, because the virus lives in saliva and easily gets onto dishes. After the illness, lasting protection is formed, so repeated cases are rare. If someone in your surroundings is ill, it is sensible not to use shared dishes and not to share a towel with them.

What symptoms can occur?

Infectious mononucleosis develops gradually, and the first changes are easily mistaken for ordinary tiredness or a cold. Below is a description of how to recognise the characteristic signs and in which cases help is needed without delay.

How it is noticed at the very beginning

Infectious mononucleosis begins with malaise, which many put down to overwork or lack of sleep. The temperature gradually rises, and the sore throat intensifies and begins to resemble tonsillitis. The lymph nodes in the neck and under the arms enlarge and become painful when palpated. Because of this, it is difficult for a person to turn their head and swallow, and the usual household tasks become harder to manage. In some people, the liver and spleen enlarge, which is felt as heaviness in the abdomen. Pronounced weakness and fatigue last longer than with an ordinary cold and make it difficult to return to work or study. If such signs have appeared and do not go away, it is sensible not to wait, but to see a doctor for an examination.

Signs that occur most often

  • High temperature: rises against a background of general malaise and lasts several days, exhausting the person and interfering with normal activity.
  • Sore throat: felt as with tonsillitis, makes swallowing difficult and often becomes the first reason to seek help.
  • Lymph nodes: in the neck and under the arms they enlarge and hurt when palpated, which is noticeable when turning the head.
  • Weakness: pronounced fatigue persists longer than usual and interferes with work, study and everyday tasks.
  • Liver and spleen: enlargement manifests as heaviness in the abdomen, so it is important to tell the doctor about this during the examination.
  • Rash: sometimes appears on the skin, including after taking antibiotics, and serves as a reason for an urgent visit.

When to seek help urgently

When to seek help urgently
SignHow urgentWhat to do
Typical symptomsRoutine visitMake an appointment with an infectious disease specialist or paediatrician
Severe abdominal painUrgentSeek help immediately
Difficulty breathingUrgentCall an ambulance
Pronounced pallorUrgentSeek medical help
Rash while taking antibioticsUrgentStop taking them and consult a doctor

Examinations and tests

Examination for infectious mononucleosis begins with a doctor's examination and a conversation, and is then confirmed by laboratory tests. Below is a breakdown of exactly which tests are used and what each of them shows.

How the examination begins

A doctor's examination helps to suspect infectious mononucleosis, because external signs are visible already at the first visit. The doctor asks in detail about the symptoms: when the weakness appeared, how long the sore throat has been troubling, whether the temperature rose. Then he examines the throat and notes the coating on the tonsils, which often accompanies this condition. Palpation of the lymph nodes shows their enlargement, especially in the neck and under the lower jaw. Palpation of the abdomen helps to identify enlargement of the liver and spleen, which is quite characteristic of mononucleosis. To confirm the diagnosis, blood tests are prescribed, which help to distinguish mononucleosis from other infections with similar complaints. Sometimes additional examination is required to assess the condition of the liver and spleen, if the examination raises concern.

What is prescribed and what it shows

What is prescribed and what it shows
ExaminationWhat it showsWhen it is prescribed
Doctor's examinationEnlargement of the lymph nodes, coating on the tonsils, enlargement of the liver and spleenAt the first appointment when an infection is suspected
Complete blood countAppearance of atypical cellsTo confirm the diagnosis
Serological testsDetection of antibodies to the virusWhen it is necessary to distinguish mononucleosis from other infections
Ultrasound examination of the abdominal organsCondition of the liver and spleenWhen their enlargement is suspected
Repeat examinationChange in the enlarged lymph nodes and organsTo assess the condition over time

What is worth preparing for the appointment

  • Discharge summaries: take the records from previous visits, they will help the doctor see how the complaints developed and when the first signs appeared.
  • Results of previous tests: bring the available blood test forms so that what has already been done is not prescribed again.
  • List of complaints: write down in advance when the temperature rose, how long the throat has been hurting and whether the lymph nodes became enlarged, so as not to forget anything.
  • Observations of the condition: note whether the appetite changed, whether weakness or heaviness in the abdomen appeared, this is important for assessing the liver and spleen.
  • Questions for the doctor: formulate in advance exactly what is unclear about the diagnosis and examinations, this way the conversation at the appointment will be more useful.

Which doctor should I see?

This section explains which doctor to consult for infectious mononucleosis, what happens at the first appointment and what the care consists of. Here you will find guidance for choosing a specialist and understanding how follow-up is organised.

Which specialist manages this condition

Infectious mononucleosis is managed by an infectious disease specialist, and in children care is also provided by a paediatrician. The infectious disease specialist deals with conditions caused by pathogens and assesses the course of the illness as a whole. The paediatrician manages young patients taking into account their age and the characteristics of their body. If there is no infectious disease specialist nearby, you can start with a paediatrician or a general practitioner at your place of residence. Such a doctor will examine the patient and, if necessary, refer them to a more specialised specialist. At the first appointment, the doctor clarifies the complaints, the medical history and examines the patient. They pay attention to enlarged lymph nodes and the condition of the liver and spleen. Further follow-up helps to notice changes in time and adjust the care.

What the treatment consists of

  • Bed rest and rest: reducing the load gives the body strength for recovery and reduces the risk of complications in the acute period.
  • Plenty of fluids: a sufficient amount of liquid maintains water balance and eases overall well-being at elevated temperature.
  • Antipyretics and painkillers as prescribed by the doctor: the specialist selects them taking into account the condition, to relieve fever and pain.
  • Monitoring the condition of the liver and spleen: these organs are involved in the process, so the doctor monitors their changes throughout the illness.
  • Hospitalisation in severe cases: if the condition worsens or complications appear, care continues in hospital under constant supervision.

What depends on the patient themselves

The regularity of follow-up with the doctor largely determines how recovery after infectious mononucleosis will proceed. Even when feeling better, it is important to attend the scheduled examinations and not miss them. The doctor assesses how the symptoms are resolving and how the liver and spleen are behaving. If a person returns to their usual activities too early, this can slow down recovery. Following the drinking regimen and rest noticeably affects the overall condition in the acute period. If new complaints appear, it is worth telling the doctor about them rather than waiting for the scheduled visit. Precise adherence to the specialist's recommendations reduces the risk of complications and repeat visits. Therefore, calm and consistent following of the prescriptions remains the most reliable support.

What helps prevent an exacerbation?

Reasonable caution in everyday life and attention to your own well-being help prevent an exacerbation of infectious mononucleosis. Below are the habits, observations and monitoring timelines that reduce the risk of repeated episodes and complications.

What to change in your habits

Infectious mononucleosis is transmitted through saliva, so habits involving close contact directly affect the course of the condition. Avoiding kisses and hugs with a person who has signs of an acute infection noticeably reduces the likelihood of reinfection. Shared dishes, towels and cutlery become a source of transmission if all family members use them indiscriminately. Washing your hands after being outside, before eating and after contact with a sick person is a simple habit that breaks the route of transmission of the pathogen. During recovery it is important to give yourself enough sleep and rest, because overfatigue lengthens the period of weakness and increases the burden on the body. It is worth limiting intense training and heavy physical work until your usual stamina returns. If pronounced fatigue, enlarged lymph nodes or a sore throat appear, it is reasonable to return to a gentle regimen and not to carry on with malaise on your feet.

What to keep under control

  • General well-being: note whether weakness and fatigue return after ordinary activities, because persistent malaise requires a doctor's attention.
  • Body temperature: measure it periodically when you feel feverish, since a repeated rise may indicate a new episode.
  • Condition of the lymph nodes: feel your neck and armpits, enlargement or tenderness of which should be shown to a specialist.
  • Sore throat: monitor its nature and duration, because prolonged inflammation makes swallowing and sleep difficult.
  • Tolerance of exertion: compare how usual activities feel now and before, so as not to miss the return of weakness.
  • Observation diary: write down changes in how you feel, this will help the doctor see the picture over time and adjust recommendations in good time.

How often to see a doctor

Regular check-ups with a doctor are needed even when your well-being seems quite satisfactory and nothing is troubling you. After an episode, the body recovers gradually, and outward well-being does not always coincide with a full return of strength. The doctor assesses the dynamics of lymph node enlargement, the condition of the throat and liver, as well as overall stamina, which change slowly and imperceptibly to the person themselves. If weakness lasts longer than usual, a sore throat appears or the temperature rises, the visit should not be postponed. With sustained improvement, routine check-ups are enough to make sure that recovery is following the expected path. Such monitoring allows an exacerbation to be noticed in time and not allowed to develop into a severe form. Write down the dates of visits and questions for the doctor in advance so that you do not forget anything at the appointment.

What is worth remembering

Infectious mononucleosis most often ends well, but it requires time and a careful attitude to one's condition. Below is the main thing that helps to make the right decision and not harm yourself.

Key conclusions

Infectious mononucleosis is a condition in which the body is weakened and requires gradual recovery, rather than a quick return to the usual workload. Weakness and enlarged lymph nodes may persist longer than the fever takes to subside, and this is the normal course of the illness. A person often feels almost healthy and therefore returns to work or study too early. Such haste leads to a protracted course and new complaints. Infectious mononucleosis is contagious, so during the acute period it is important to limit close contacts with others. If the condition worsens or new alarming signs appear, a visit to the doctor must not be postponed. The basis for a decision is not how one feels on a particular day, but the specialist's conclusion and the results of examinations.

Portal Editorial TeamMedical editorial team

Covers what does not belong to a single specialty: how an appointment works, what to bring with you, how to read a referral. Every text is reviewed by a relevant doctor before publication.

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Questions and answers

Answered by the article’s medical editor.

How can infectious mononucleosis be distinguished from ordinary tonsillitis?

Usually a doctor does this by examination and blood tests. In infectious mononucleosis, weakness lasts longer, and the lymph nodes enlarge not only near the throat but also in the neck and under the arms. Tonsillitis more often has a more acute onset and responds to treatment more quickly. It is difficult to distinguish these conditions on your own, so an examination is needed.

Does infectious mononucleosis occur in small children?

Yes, children fall ill often, but in little ones the illness frequently passes in a mild, indistinct form. It is easily mistaken for an ordinary cold: fever, a runny nose, lethargy, refusal to eat. The pronounced picture with a coating on the tonsils is more often seen in adolescents and young adults. If a child is lethargic for a long time, they should be shown to a paediatrician.

How do elderly people cope with infectious mononucleosis?

Usually less often than young people, but they cope with it more severely. In older people, weakness is more pronounced, and recovery is slower. Fatigue and prolonged malaise come to the fore, rather than a severe sore throat. Therefore, it is especially important for such patients to be monitored by a doctor.

Can you get infectious mononucleosis a second time?

Usually not: after the illness, lasting protection forms, so repeat cases are rare. The virus remains in the body, but in a dormant state, and does not cause the illness again. If similar symptoms return, it is more often a different pathogen. In that case, the doctor prescribes tests to clarify the cause.

Is infectious mononucleosis dangerous for pregnant women?

The virus itself is usually not dangerous for the course of pregnancy, but an assessment of the woman's condition by a doctor is important. Weakness and high fever are harder to cope with, and enlargement of the liver and spleen requires monitoring. Therefore, a pregnant woman should report her symptoms to her obstetrician-gynaecologist and physician. They will decide whether additional tests are needed.

What complications occur with infectious mononucleosis?

Most often everything ends well, but complications are possible. The liver and spleen are the most vulnerable: their enlargement requires caution and limitation of exertion. Sometimes a bacterial throat infection is added, or changes in the blood occur. With severe abdominal pain or difficulty breathing, help is needed urgently.

When should an ambulance be called for infectious mononucleosis?

Immediately, if difficulty breathing or severe abdominal pain appears. Pronounced pallor, fainting and a sharp deterioration in general condition are also alarming. A rash while taking antibiotics is also a reason to see a doctor urgently. In these cases, one cannot wait for a scheduled appointment.

Can you work and study during the illness?

No, during the acute period rest and relaxation at home are needed. Weakness and fever make it hard to concentrate, and close contacts in a group contribute to transmission of the virus. It is worth returning to work or study gradually, as strength is restored. The timing is best agreed with a doctor.

When can you return to sport after infectious mononucleosis?

Not before the doctor allows it, usually several weeks after improvement. The liver and spleen enlarge and remain vulnerable, so sudden exertion and abdominal injuries are dangerous. It is worth starting with light activity and monitoring how you feel. If weakness returns, the exertion is reduced.

How long do you need to be monitored by a doctor?

Usually several weeks after improvement; the exact timing is determined by the specialist. Weakness and enlarged lymph nodes go away more slowly than fever and require monitoring. The doctor assesses the condition of the liver and spleen over time. With sustained improvement, visits become scheduled and less frequent.